Reference - Detail
| RRC ID | 87680 |
|---|---|
| Author | Du XM, Suo F, Du LL. |
| Title | Gene loss, repression, amplification, and horizontal acquisition shape galactose/melibiose metabolism in fission yeast. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Natural variation in metabolism is a key driver of microbial adaptation. While galactose utilization is well studied in budding yeasts, it remains poorly understood in the fission yeast Schizosaccharomyces pombe. Here, we reveal extensive natural variation in galactose utilization across S. pombe isolates-from complete deficiency (Gal-) to exceptionally fast growth (GalF). Gal- strains fall into two classes: one with deletions of the gal gene cluster (via three distinct mechanisms) and another with intact but repressed gal genes. In contrast, GalF is driven by an amplified gene cluster absent from the reference genome-the gal-mel cluster (GMC)-which also confers melibiose utilization (Mel+). Mel+ is exclusively linked to the GMC, except in one strain harboring a standalone melibiase gene. Phylogenetic analyses indicate that horizontal gene transfer may underlie these adaptive traits. Together, our work demonstrates how diverse mechanisms-gene loss, repression, amplification, and horizontal acquisition-shape metabolic diversity and ecological specialization in fission yeast. |
| Volume | 123(17) |
| Pages | e2532532123 |
| Published | 2026-4-28 |
| DOI | 10.1073/pnas.2532532123 |
| PMID | 42030144 |
| MeSH | Galactose* / metabolism Gene Amplification Gene Deletion Gene Expression Regulation, Fungal Gene Transfer, Horizontal Melibiose* / metabolism Multigene Family Phylogeny Schizosaccharomyces* / genetics Schizosaccharomyces* / metabolism |
| IF | 9.412 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 10.2 |
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