| RRC ID |
87705
|
| Author |
Nishiike Y, Maki S, Miyazoe D, Nakasone K, Kamei Y, Todo T, Ishikawa-Fujiwara T, Ohno K, Usami T, Nagahama Y, Okubo K.
|
| Title |
Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka.
|
| Journal |
Elife
|
| Abstract |
In rodents, estrogens aromatized from androgens in the brain are essential for the development of male-typical behaviors. In many other vertebrates, including humans and teleost fish, however, androgens facilitate these behaviors directly via the androgen receptor without aromatization into estrogens. Here, we report that mutagenesis-derived male medaka fish lacking Cyp19a1b (a subtype of aromatase predominantly expressed in the brain) exhibit severely impaired male-typical mating and aggression, despite elevated brain androgen levels. These phenotypes can be rescued by estrogen administration, indicating that brain-derived estrogens are pivotal for male-typical behaviors even in teleosts. Our results further suggest that these estrogens facilitate male-typical behaviors by potentiating androgen action in the brain via the direct stimulation of androgen receptor transcription. Taken together, these findings reveal a previously unappreciated mode of action of brain-derived estrogens in facilitating male-typical behaviors.
|
| Volume |
13
|
| Published |
2026-1-13
|
| DOI |
10.7554/eLife.97106
|
| PII |
97106
|
| PMID |
41527437
|
| PMC |
PMC12799210
|
| MeSH |
Aggression
Animals
Aromatase / genetics
Aromatase / metabolism
Brain* / metabolism
Estrogens* / metabolism
Male
Oryzias* / physiology
Receptors, Androgen* / metabolism
Sexual Behavior, Animal*
Signal Transduction*
|
| IF |
7.08
|
| Resource |
| Medaka |
d-rR/TOKYO
olova36n18
ola1-111G01
ola1-192H15 |
