論文 - 詳細
| RRC ID | 87718 |
|---|---|
| 著者 | Naruse K, Loosli F, Ansai S, Birney E, Wittbrodt J. |
| タイトル | Medaka: a novel model for analyzing genome-environment interactions. |
| ジャーナル | Trends Genet |
| Abstract |
Medaka is an established vertebrate model system for biological and biomedical research. It possesses unique features that make it particularly suitable for studying genome-environment interactions. Endemic to habitats spanning from 4 to 40°C and varying salinities, it combines broad ecological adaptability with experimental tractability. Its exceptional tolerance to inbreeding enabled the creation of the Medaka Inbred Kiyosu-Karlsruhe panel-80 near-isogenic, fully sequenced lines derived from a single wild population. More than 100 wild-derived, fully sequenced strains, collected throughout East Asia for more than 40 years, show relatively low intra-strain variation (inbreeding coefficient of >0.75) but high inter-strain variability (SNP rates >4%). Advanced quantification methods facilitate genome-wide association studies and quantitative trait locus mapping. The system's amenability to clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 editing and emerging epigenomic profiling enables causal validation and regulatory-mechanism discovery. Collectively, medaka offers an unparalleled vertebrate framework for integrating genetics, environment, and epigenetics-bridging evolutionary, biomedical, and population-level perspectives. |
| 巻・号 | 42(4) |
| ページ | 350-361 |
| 公開日 | 2026-4-1 |
| DOI | 10.1016/j.tig.2025.12.005 |
| PII | S0168-9525(25)00315-4 |
| PMID | 41735098 |
| MeSH | Animals CRISPR-Cas Systems Gene-Environment Interaction* Genome* Genome-Wide Association Study Oryzias* / genetics Quantitative Trait Loci |
| IF | 11.333 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 14.2 |
| リソース情報 | |
| メダカ | IB176 |