論文 - 詳細
| RRC ID | 87808 |
|---|---|
| 著者 | Tomoya Nakayama, Taiki Yamaguchi, Michiyo Maruyama, Satoshi Ansai, Makoto Kashima, Romain Fontaine, Christiaan Henkel, Kiyoshi Naruse, Takashi Yoshimura |
| タイトル | Photoperiod decoder 1 regulates seasonal changes in energy metabolism through the growth hormone signaling pathway |
| Abstract |
Seasonal changes in metabolism are crucial for animals to adapt to annual environmental fluctuations. However, the molecular mechanisms underlying these adaptations remain poorly understood. Here, we identified a novel gene,
photoperiod decoder 1
(
phod1
), which exhibits a unique bimodal expression pattern under long-day conditions in Japanese medaka fish (
Oryzias latipes
). While
phod1
is conserved across many vertebrates, except for eutherians, its function remained unknown. Single-cell RNA sequencing analysis revealed that
phod1
is predominantly expressed in specific pituitary cells that co-express opsin and circadian clock genes. Transcriptomic analysis using
phod1
knockout fish demonstrated that
phod1
is essential for photoperiodic regulation of growth hormone. Furthermore, transcriptomic and metabolomic analyses of the liver, the primary target of growth hormone, revealed significant alterations in energy metabolism. Behavioral analysis also showed that
phod1
knockout fish exhibited significantly reduced locomotor activity. These findings indicate that
phod1
plays a crucial role in seasonal metabolic adaptation through modulation of the growth hormone signaling pathway. |
| DOI | 10.1101/2025.02.19.638565 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | |