論文 - 詳細
| RRC ID | 87834 |
|---|---|
| 著者 | Nakanaga S, Takahashi T, Kuma A, Kawahara H. |
| タイトル | The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes. |
| ジャーナル | FEBS Lett |
| Abstract |
Lysosomes play a critical role in the quality control of cellular organelles. However, lysosomal membranes can be damaged under a variety of conditions, leading to the onset of various diseases. Damaged lysosomes are selectively cleared via a ubiquitin-dependent mechanism, but the molecular mechanisms underlying this process have not been adequately elucidated. In this study, we found that RNF115 is a lysosomal damage-responsive ubiquitin ligase that undergoes massive translocation from the cytosol to the p62/SQSTM1-positive puncta around ruptured lysosomes. In accordance with the changes in its distribution, the depletion of RNF115 delayed the removal of Gal3 from damaged lysosomes during the restoration process following lysosomal damage. These observations suggest that RNF115 is responsible for the clearance of damaged lysosomes. |
| 公開日 | 2026-4-24 |
| DOI | 10.1002/1873-3468.70346 |
| PMID | 42032884 |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Peer-review(Publons) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.2 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |