論文 - 詳細
| RRC ID | 87851 |
|---|---|
| 著者 | Yukina Akama, Shunsuke Maeda, Miyako Udono, Utano Nakamura, Yusuke Yamashita, Youngil Kim, Bungo Shirouchi, Kiichiro Teruya, Yoshinori Katakura |
| タイトル | GABA-Induced Exosomes Improve Memory Impairment in Aged Mice |
| ジャーナル | International Journal of Molecular Sciences |
| Abstract |
Gamma-aminobutyric acid (GABA) has been implicated in gut–brain interactions and neuronal activation. We hypothesized that GABA could ameliorate memory decline. We investigated whether oral GABA administration ameliorated age-related cognitive decline in aged mice (C57BL/6J, male) and explored the role of circulating exosomes in mediating these effects. Aged mice that drank water containing 0.5% GABA exhibited significantly improved discrimination index scores compared with that of controls, indicating enhanced memory function. Their plasma-derived exosomes induced neurite outgrowth and mitochondrial activation and restored neuronal activity in SH-SY5Y cells. GABA enhanced the exosomal expression of several miRNAs linked to neuronal activation, longevity, and anti-senescence pathways. Plasma-derived exosomes also restored object recognition memory, reduced hippocampal neuroinflammation, and decreased senescent cell markers (p21 and γH2AX) in aged mice. Additionally, mitochondria- and neurite-related genes were upregulated, and pathways associated with oxidative phosphorylation and Alzheimer’s disease were enriched. Collectively, long-term GABA administration was found to improve cognitive function of aged mice through the secretion of functional exosomes. |
| 巻・号 | 27 |
| ページ | 2519 |
| 公開日 | 2026-3-10 |
| DOI | 10.3390/ijms27062519 |
| PMID | 41898384 |
| PMC | PMC13026798 |
| MeSH | Aging* Animals Exosomes* / drug effects Exosomes* / metabolism Hippocampus / drug effects Hippocampus / metabolism Humans Male Memory Disorders* / drug therapy Memory Disorders* / metabolism Mice Mice, Inbred C57BL MicroRNAs / genetics MicroRNAs / metabolism Mitochondria / drug effects Mitochondria / metabolism gamma-Aminobutyric Acid* / pharmacology |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 2.5 |
| リソース情報 | |
| 加齢マウス | |