| RRC ID |
87851
|
| 著者 |
Yukina Akama, Shunsuke Maeda, Miyako Udono, Utano Nakamura, Yusuke Yamashita, Youngil Kim, Bungo Shirouchi, Kiichiro Teruya, Yoshinori Katakura
|
| タイトル |
GABA-Induced Exosomes Improve Memory Impairment in Aged Mice
|
| ジャーナル |
International Journal of Molecular Sciences
|
| Abstract |
Gamma-aminobutyric acid (GABA) has been implicated in gut–brain interactions and neuronal activation. We hypothesized that GABA could ameliorate memory decline. We investigated whether oral GABA administration ameliorated age-related cognitive decline in aged mice (C57BL/6J, male) and explored the role of circulating exosomes in mediating these effects. Aged mice that drank water containing 0.5% GABA exhibited significantly improved discrimination index scores compared with that of controls, indicating enhanced memory function. Their plasma-derived exosomes induced neurite outgrowth and mitochondrial activation and restored neuronal activity in SH-SY5Y cells. GABA enhanced the exosomal expression of several miRNAs linked to neuronal activation, longevity, and anti-senescence pathways. Plasma-derived exosomes also restored object recognition memory, reduced hippocampal neuroinflammation, and decreased senescent cell markers (p21 and γH2AX) in aged mice. Additionally, mitochondria- and neurite-related genes were upregulated, and pathways associated with oxidative phosphorylation and Alzheimer’s disease were enriched. Collectively, long-term GABA administration was found to improve cognitive function of aged mice through the secretion of functional exosomes.
|
| 巻・号 |
27
|
| ページ |
2519
|
| 公開日 |
2026-3-10
|
| DOI |
10.3390/ijms27062519
|
| PMID |
41898384
|
| PMC |
PMC13026798
|
| MeSH |
Aging*
Animals
Exosomes* / drug effects
Exosomes* / metabolism
Hippocampus / drug effects
Hippocampus / metabolism
Humans
Male
Memory Disorders* / drug therapy
Memory Disorders* / metabolism
Mice
Mice, Inbred C57BL
MicroRNAs / genetics
MicroRNAs / metabolism
Mitochondria / drug effects
Mitochondria / metabolism
gamma-Aminobutyric Acid* / pharmacology
|
| IF |
4.556
|
| リソース情報 |
| 加齢マウス |
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