Reference - Detail
| RRC ID | 87907 |
|---|---|
| Author | Sakaue M, Yamamoto A, Onishi T, Oyabu M, Kamei Y. |
| Title | Compounds Identified by Screening that Inhibit the Activity of Transcription Factor FOXO1/3a Suppress Dexamethasone-Induced Atrogin1 Expression in C2C12 Myoblasts. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Using a reporter assay system we screened a library of 472 compounds, and identified 1,25(OH)2D3, all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis-retinoic acid, 17-allylamino-17-demethoxygeldanamycin, cantharidin and magnolol that inhibit FOXO1/3a activity. These compounds suppressed the increase in Atrogin1 gene expression induced by dexamethasone in C2C12 myoblasts. Therefore, these compounds may prevent muscle atrophy by inhibiting FOXO1/3a activity. |
| Published | 2026-3-6 |
| DOI | 10.1093/bbb/zbag033 |
| PII | 8509309 |
| PMID | 41790122 |
| Resource | |
| Human and Animal Cells | C2C12(RCB0987) |