論文 - 詳細
| RRC ID | 87955 |
|---|---|
| 著者 | Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, Sigal LJ. |
| タイトル | Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. |
| ジャーナル | Immunity |
| Abstract |
Toll-like receptor 9 (TLR9), its adaptor MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interferons (IFN-I) are all required for resistance to infection with ectromelia virus (ECTV). However, it is not known how or in which cells these effectors function to promote survival. Here, we showed that after infection with ECTV, the TLR9-MyD88-IRF7 pathway was necessary in CD11c(+) cells for the expression of proinflammatory cytokines and the recruitment of inflammatory monocytes (iMos) to the draining lymph node (dLN). In the dLN, the major producers of IFN-I were infected iMos, which used the DNA sensor-adaptor STING to activate IRF7 and nuclear factor κB (NF-κB) signaling to induce the expression of IFN-α and IFN-β, respectively. Thus, in vivo, two pathways of DNA pathogen sensing act sequentially in two distinct cell types to orchestrate resistance to a viral disease. |
| 巻・号 | 43(6) |
| ページ | 1148-59 |
| 公開日 | 2015-12-15 |
| DOI | 10.1016/j.immuni.2015.11.015 |
| PII | S1074-7613(15)00493-8 |
| PMID | 26682986 |
| PMC | PMC4684903 |
| MeSH | Animals DNA Virus Infections / immunology Ectromelia virus Ectromelia, Infectious / immunology Flow Cytometry Interferon Regulatory Factor-7 / immunology Interferon Type I / biosynthesis Interferon Type I / immunology* Lymph Nodes / immunology Membrane Proteins / immunology Mice Mice, Knockout Mice, Mutant Strains Monocytes / immunology* Myeloid Differentiation Factor 88 / immunology Reverse Transcriptase Polymerase Chain Reaction STING Protein Signal Transduction / immunology* Toll-Like Receptor 9 / immunology |
| IF | 22.553 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00858 RBRC01420 |