| RRC ID |
87972
|
| Author |
Dennis N, Vazquez-Prada M, Freeman LM, Xue F, White LJ, Karamalegos AA, Sullivan WG, Kudzminkaite B, Brown I, Hiscock JR, Ezcurra M.
|
| Title |
A microbial community that alters mitochondrial morphology and age-related motor function in C. elegans.
|
| Journal |
iScience
|
| Abstract |
Across diverse taxa, the composition of the microbiota is associated with host fitness. A mechanistic understanding of how microbial communities influence host physiology could lead to microbiota-based interventions for lifelong health. Here, we have developed a host-microbiota model system consisting of the model organism C. elegans combined with a defined natural microbiota (DefNatMta) consisting of 11 bacterial strains isolated from wild C. elegans to study natural host-microbiota interactions in the laboratory. We show that DefNatMta persists in the C. elegans gut, forming a stable and distinct gut microbiota. Utilizing this host-microbiota system, we find that DefNatMta affects age-related motility and protects against age-related decline in motor function. DefNatMta acts by altering metabolism and mitochondrial network dynamics in muscle and requires dynamin-related protein 1 (DRP-1), a regulator of mitochondrial fission to protect against age-related motility decline. Our findings are consistent with microbe-mitochondria communication affecting age-related muscle function.
|
| Volume |
28(12)
|
| Pages |
114128
|
| Published |
2025-12-19
|
| DOI |
10.1016/j.isci.2025.114128
|
| PII |
S2589-0042(25)02389-2
|
| PMID |
41438044
|
| PMC |
PMC12721190
|
| Resource |
| C.elegans |
tm1108 |
