論文 - 詳細
| RRC ID | 87980 |
|---|---|
| 著者 | White AM, Bauer AD, Faumont S, Lockery SR. |
| タイトル | Behavioral and genetic analysis of the effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) in C. elegans. |
| ジャーナル | PLoS One |
| Abstract |
Psychedelics show promise in treating depression, PTSD, and substance use disorder, prompting research into their mechanisms of action. Most studies use rodent models, but genetic tools can be challenging to apply in this approach. Invertebrate models, like C. elegans, offer a cost-effective alternative with short generation times and genetic tractability. This study examined the worm's response to the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) by assessing four serotonergic behaviors. Effects of DOI exposure on locomotion speed, swimming frequency, and egg-laying were undetectable, but DOI strongly inhibited feeding. Interestingly, this effect was independent of serotonin receptors, suggesting DOI may act through alternative pathways. These findings indicate that C. elegans can serve as a useful model for studying psychedelic drug effects, potentially revealing novel mechanisms beyond the serotonergic system. Further research could help clarify these pathways, improving our understanding of the therapeutic potential of psychedelics and refining their efficacy in treating neuropsychiatric disorders. |
| 巻・号 | 20(8) |
| ページ | e0329538 |
| 公開日 | 2025-1-1 |
| DOI | 10.1371/journal.pone.0329538 |
| PII | PONE-D-25-16388 |
| PMID | 40857291 |
| PMC | PMC12380321 |
| MeSH | Amphetamines* / pharmacology Animals Behavior, Animal* / drug effects Caenorhabditis elegans* / drug effects Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Hallucinogens* / pharmacology Locomotion / drug effects Receptors, Serotonin / metabolism Serotonin / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1325 tm3712 |