論文 - 詳細
| RRC ID | 88056 |
|---|---|
| 著者 | Serot C, Scarcelli V, Pouget A, Largeau C, Sagot A, El-Hachami K, Dupuy D, Culetto E, Lefebvre C, Legouis R. |
| タイトル | Reticulon-dependent ER-phagy mediates adaptation to heat stress in C. elegans. |
| ジャーナル | Curr Biol |
| Abstract |
The selective degradation of endoplasmic reticulum (ER) by autophagy, named ER-phagy, promotes the recovery of ER homeostasis after stress. Depending on the ER stress, different types of ER-phagy involve various selective autophagy receptors. In this study, we report a macroER-phagy induced by the fragmentation of tubular ER in response to acute heat stress. We identified a novel ER-phagy receptor encoded by the reticulon long isoform RET-1d. RET-1d is mainly expressed in the nervous system and the epidermis and colocalizes with the ubiquitin-like autophagy protein LGG-1/GABARAP during heat-stress-induced autophagy. Two LC3-interacting region (LIR) motifs in the long intrinsically disordered region of RET-1d mediate its interaction with the LGG-1 protein. The specific depletion of the RET-1d isoform or the mutations of the LIRs resulted in a defective ER-phagy and a decrease in the capacity of animals to adapt to heat stress. Our data revealed a RET-1d- and LGG-1-dependent ER-phagy mechanism that takes place in neurons and epidermis and participates in the adaptation of C. elegans to heat stress. |
| 巻・号 | 35(10) |
| ページ | 2365-2378.e7 |
| 公開日 | 2025-5-19 |
| DOI | 10.1016/j.cub.2025.04.028 |
| PII | S0960-9822(25)00457-9 |
| PMID | 40328253 |
| MeSH | Adaptation, Physiological Animals Autophagy* / physiology Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Endoplasmic Reticulum* / metabolism Endoplasmic Reticulum Stress* Heat-Shock Response* / physiology |
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm390 |