論文 - 詳細
| RRC ID | 88066 |
|---|---|
| 著者 | Chen M, Gong J. |
| タイトル | The seminal fluid protein SFP-1 regulates mated hermaphrodite aging and fat metabolism in C. elegans. |
| ジャーナル | EMBO J |
| Abstract |
Across the evolutionary spectrum, sexual interactions can significantly influence the physiology and somatic aging in various species. In Caenorhabditis, male pheromones, sperm, and seminal fluid shorten the lifespan of hermaphrodites through different mechanisms. However, the specific male seminal fluid proteins responsible for this effect remain unidentified. Here, we find that several of the previously observed physiological changes in mated hermaphrodites require a newly-identified seminal fluid protein. SFP-1 is packaged into secretory vesicles via the phospholipid scramblases ANOH-1 and ANOH-2 in male seminal vesicles, and after mating taken up by intestinal cells via endocytosis. Within these intestinal cells, the NTF2-like domain of SFP-1 interacts with and activates the transcription factor SKN-1, which induces post-mating somatic fat depletion and lifespan reduction. Together, these results define how a male seminal-fluid protein can trigger mating-induced physiological changes in sexual interactions. |
| 巻・号 | 44(23) |
| ページ | 7181-7210 |
| 公開日 | 2025-12-1 |
| DOI | 10.1038/s44318-025-00610-1 |
| PII | 10.1038/s44318-025-00610-1 |
| PMID | 41145916 |
| PMC | PMC12669617 |
| MeSH | Aging* Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism Female Hermaphroditic Organisms* / metabolism Hermaphroditic Organisms* / physiology Lipid Metabolism* Male Phospholipid Transfer Proteins / genetics Phospholipid Transfer Proteins / metabolism Seminal Plasma Proteins* / genetics Seminal Plasma Proteins* / metabolism Sexual Behavior, Animal Transcription Factors / genetics Transcription Factors / metabolism |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4762 tm4796 |