論文 - 詳細
| RRC ID | 88082 |
|---|---|
| 著者 | Yokosawa R, Noma K. |
| タイトル | A Nuclear Hormone Receptor nhr-76 Induces Age-Dependent Chemotaxis Decline in C. elegans. |
| ジャーナル | Aging Cell |
| Abstract |
A decline in food-searching behavior of post-reproductive animals can benefit the population and possibly be programmed by the genome despite its detrimental effect on an individual. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a novel forward genetic screen, we identified the gene encoding a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that NHR-76 downregulates odorant receptor expression during aging in a ligand-binding-domain-dependent manner. Since NHR-76 expression and localization remain unchanged with age, its activity may be modulated through the ligand-binding domain, leading to age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed. |
| 巻・号 | 24(12) |
| ページ | e70277 |
| 公開日 | 2025-12-1 |
| DOI | 10.1111/acel.70277 |
| PMID | 41128441 |
| PMC | PMC12686552 |
| MeSH | Aging* / genetics Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Chemotaxis* / genetics Receptors, Cytoplasmic and Nuclear* / genetics Receptors, Cytoplasmic and Nuclear* / metabolism Receptors, Odorant / genetics Receptors, Odorant / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm671 tm4063 tm2146 |