Reference - Detail
| RRC ID | 88132 |
|---|---|
| Author | Kitto ES, Beydoun S, Henry E, Schaller ML, Bhandari M, Easow SA, Tuckowski AM, Howington MB, Bhat A, Sridhar A, Chung E, Evans CR, Leiser SF. |
| Title | Metabolic regulation of behavior by the intestinal enzyme FMO-2. |
| Journal | Sci Adv |
| Abstract |
Many elements of an organism's behavior are intertwined with the organism's health. Over a long period of time, health status is also indicative of life span, with improved health correlating with a longer life. However, the relationship between longevity and behavior remains relatively unexplored. Here, we report that modification of a single longevity gene downstream of dietary restriction and hypoxia markedly alters behavior in Caenorhabditis elegans. We found that modified expression of flavin-containing monooxygenase (fmo-2) leads to altered sensory perception and decision-making in a variety of behavioral paradigms. This cell nonautonomous signaling pathway is linked to changes in tryptophan metabolism, where loss of fmo-2 requires the tryptophan metabolite serotonin and overexpressed fmo-2 requires the tryptophan metabolite quinolinic acid to change behavior. These results suggest a unique mechanism for gut metabolism to communicate positive satiety signals and negative depressive signals to the organism by modifying an essential amino acid. They also demonstrate the importance of examining pleiotropic effects in promising longevity interventions. |
| Volume | 11(43) |
| Pages | eadx3018 |
| Published | 2025-10-24 |
| DOI | 10.1126/sciadv.adx3018 |
| PMID | 41134904 |
| PMC | PMC12551704 |
| MeSH | Animals Behavior, Animal* Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Intestinal Mucosa* / metabolism Intestines* / enzymology Longevity / genetics Oxygenases* / genetics Oxygenases* / metabolism Serotonin / metabolism Signal Transduction Tryptophan / metabolism |
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| The most frequently cited source | News |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm4547 tm4924 tm4627 |