論文 - 詳細
| RRC ID | 88180 |
|---|---|
| 著者 | Morimoto M, Saito D. |
| タイトル | Avian primordial germ cell migration: History, mechanisms, applications, and unanswered questions. |
| ジャーナル | Protein Expr Purif |
| Abstract |
Since Swift's discovery of primordial germ cells (PGCs) within the vasculature of chicken embryos in 1914, significant progress has been made in uncovering the origins, migratory pathways, and molecular characteristics of avian PGCs. Recent advances in this field have been accelerated by two synergistic factors: the establishment of robust culture systems that enable efficient genetic manipulation of chicken PGCs, and the inherent suitability of avian embryos for cell transplantation and live imaging. Together, these features have positioned avian PGCs as a powerful system for investigating not only cell migration but also long-standing mysteries in germ cell biology. Furthermore, this system offers a unique platform for dissecting the cellular and molecular mechanisms underlying diseases such as cancer metastasis and germ cell tumors. In this review, we revisit key historical milestones in avian PGC research, explore current knowledge of their migratory regulation, and highlight future directions with potential impact across cell biology, developmental biology, and disease modeling. |
| 巻・号 | 235 |
| ページ | 106788 |
| 公開日 | 2025-11-1 |
| DOI | 10.1016/j.pep.2025.106788 |
| PII | S1046-5928(25)00130-5 |
| PMID | 40752581 |
| MeSH | Animals Cell Movement* Chick Embryo Chickens Germ Cells* / cytology Germ Cells* / metabolism History, 20th Century |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニワトリ・ウズラ | |