論文 - 詳細
| RRC ID | 88354 |
|---|---|
| 著者 | Hirata T, Song S, Seki K, Taniguchi M, Ishihara A, Ichiyanagi T, Aimi T. |
| タイトル | Purification and structural characterization of an anti-Trichophyton compound produced by Auricularia heimuer mycelium. |
| ジャーナル | Mycoscience |
| Abstract |
In this study, by screening approximately 160 mushroom extracts for anti-Trichophyton activity, significant activity was found in the culture filtrate of the Auricularia heimuer TUFC 100803 strain. To purify the active compound, the strain was cultured in 2.0 L of malt liquid medium, and the culture filtrate was extracted with ethyl acetate. The resulting crude extract was fractionated by silica-gel chromatography and preparative thin-layer chromatography, and a pure active compound, designated heimuerol A, was successfully isolated. According to IUPAC nomenclature, the compound was identified as (1R,2R,5R)-2-(prop-1-en-2-yl)-6-oxabicyclo[3.1.0]hex-3-en-2-ol. Unlike terbinafine, which is used as both a topical and oral medication for tinea, heimuerol A lacks a nitrogen and possesses a structure containing an epoxide group and a five-membered ring. The minimum inhibitory concentration (MIC) of terbinafine-resistant strains was lower than that for wild-type strains when treated with heimuerol A. Furthermore, a mixture of heimuerol A and terbinafine exhibited activity at concentrations lower than their respective MICs. These findings suggest that heimuerol A inhibits ergosterol biosynthesis through a mechanism distinct from that of terbinafine. |
| 巻・号 | 67(2) |
| ページ | 27-31 |
| 公開日 | 2026-1-1 |
| DOI | 10.47371/mycosci.2025.12.001 |
| PMID | 42052162 |
| PMC | PMC13112066 |
| IF | 1.172 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.0 |
| リソース情報 | |
| きのこ | TUFC 100803 |