論文 - 詳細
| RRC ID | 88460 |
|---|---|
| 著者 | Tacconi C, Commerford CD, Dieterich LC, Schwager S, He Y, Ikenberg K, Friebel E, Becher B, Tugues S, Detmar M. |
| タイトル | CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis. |
| ジャーナル | Cell Rep |
| Abstract |
Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169+ macrophages as the predominant macrophage subtype in naive LNs, which undergo proliferative expansion in response to tumor stimuli. CD169+ LN macrophage depletion, using an anti-CSF-1R antibody or clodronate-loaded liposomes, leads to increased metastatic burden in two mouse breast cancer models. The expansion of CD169+ macrophages is tightly connected to B cell expansion in tumor-draining LNs, and B cell depletion abrogates the effect of CD169+ macrophage absence on metastasis, indicating that the CD169+ macrophage anti-metastatic effects require B cell presence. These results reveal a protective role of CD169+ LN macrophages in breast cancer metastasis and raise caution for the use of drugs aiming at the depletion of tumor-associated macrophages, which might simultaneously deplete macrophages in tumor-draining LNs. |
| 巻・号 | 35(2) |
| ページ | 108993 |
| 公開日 | 2021-4-13 |
| DOI | 10.1016/j.celrep.2021.108993 |
| PII | S2211-1247(21)00307-7 |
| PMID | 33852863 |
| MeSH | Animals B-Lymphocytes / immunology B-Lymphocytes / pathology Biomarkers / metabolism Cell Proliferation Female Gene Expression Humans Lung Neoplasms / genetics Lung Neoplasms / immunology* Lung Neoplasms / pathology Lymph Nodes / immunology* Lymph Nodes / pathology Lymphatic Metastasis Macrophages / cytology Macrophages / immunology* Mammary Glands, Animal / immunology* Mammary Glands, Animal / pathology Mammary Neoplasms, Experimental / genetics Mammary Neoplasms, Experimental / immunology* Mammary Neoplasms, Experimental / pathology Mice Mice, Inbred BALB C Monocytes / immunology Monocytes / pathology Sialic Acid Binding Ig-like Lectin 1 / genetics* Sialic Acid Binding Ig-like Lectin 1 / immunology Tumor Burden |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC04395 |