| RRC ID |
88460
|
| 著者 |
Tacconi C, Commerford CD, Dieterich LC, Schwager S, He Y, Ikenberg K, Friebel E, Becher B, Tugues S, Detmar M.
|
| タイトル |
CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169+ macrophages as the predominant macrophage subtype in naive LNs, which undergo proliferative expansion in response to tumor stimuli. CD169+ LN macrophage depletion, using an anti-CSF-1R antibody or clodronate-loaded liposomes, leads to increased metastatic burden in two mouse breast cancer models. The expansion of CD169+ macrophages is tightly connected to B cell expansion in tumor-draining LNs, and B cell depletion abrogates the effect of CD169+ macrophage absence on metastasis, indicating that the CD169+ macrophage anti-metastatic effects require B cell presence. These results reveal a protective role of CD169+ LN macrophages in breast cancer metastasis and raise caution for the use of drugs aiming at the depletion of tumor-associated macrophages, which might simultaneously deplete macrophages in tumor-draining LNs.
|
| 巻・号 |
35(2)
|
| ページ |
108993
|
| 公開日 |
2021-4-13
|
| DOI |
10.1016/j.celrep.2021.108993
|
| PII |
S2211-1247(21)00307-7
|
| PMID |
33852863
|
| MeSH |
Animals
B-Lymphocytes / immunology
B-Lymphocytes / pathology
Biomarkers / metabolism
Cell Proliferation
Female
Gene Expression
Humans
Lung Neoplasms / genetics
Lung Neoplasms / immunology*
Lung Neoplasms / pathology
Lymph Nodes / immunology*
Lymph Nodes / pathology
Lymphatic Metastasis
Macrophages / cytology
Macrophages / immunology*
Mammary Glands, Animal / immunology*
Mammary Glands, Animal / pathology
Mammary Neoplasms, Experimental / genetics
Mammary Neoplasms, Experimental / immunology*
Mammary Neoplasms, Experimental / pathology
Mice
Mice, Inbred BALB C
Monocytes / immunology
Monocytes / pathology
Sialic Acid Binding Ig-like Lectin 1 / genetics*
Sialic Acid Binding Ig-like Lectin 1 / immunology
Tumor Burden
|
| IF |
8.109
|
| リソース情報 |
| 実験動物マウス |
RBRC04395 |
