| Abstract |
Edwardsiella piscicida is a potent intracellular pathogen that infects a wide variety of freshwater and marine fish, causing systemic hemorrhagic sepsis that results in lethality. Although vaccines against E. piscicida have been developed for many fish species, a direct comparison between innate and adaptive immunity in protecting fish from E. piscicida infection has not been performed. We established an il2rb mutant lacking natural killer (NK) cells, innate type lymphocytes, showing that NK cells are required for protection against E. piscicida infection in adult medaka. In addition, we elucidated the role of the TLR signaling pathway transmitted by Myd88 in resistance to E. piscicida infection in larvae and adults. These results indicate the requirement of innate immunity in resistance to this intracellular pathogen, providing insights into vaccination strategies for fish.
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