Reference - Detail
| RRC ID | 88539 |
|---|---|
| Author | Mihara Y, Ishimoto T, Ozasa R, Omura T, Yamato Y, Yamada T, Okamoto A, Matsuyama Y, Nakano T. |
| Title | Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs. |
| Journal | J Bone Miner Metab |
| Abstract |
INTRODUCTION:The discrepancy between bone mineral density (BMD), the gold standard for bone assessment, and bone strength is a constraint in diagnosing bone function and determining treatment strategies for several bone diseases. Gastric hypochlorhydria induced by clinically used proton pump inhibitor (PPI) therapy indicates a discordance between changes in BMD and bone strength. Here, we used Cckbr-deficient mice with gastric hypochlorhydria to examine the effect of gastric hypochlorhydria on bone mass, BMD, and preferential orientation of the apatite crystallites, which is a strong indicator of bone strength. MATERIALS AND METHODS:Cckbr-deficient mice were created, and their femurs were analyzed for BMD and preferential orientation of the apatite c-axis along the femoral long axis. RESULTS:Cckbr-deficient mouse femurs displayed a slight osteoporotic bone loss at 18 weeks of age; however, BMD was comparable to that of wild-type mice. In contrast, apatite orientation in the femur mid-shaft significantly decreased from 9 to 18 weeks. To the best of our knowledge, this is the first report demonstrating the deterioration of apatite orientation in the bones of Cckbr-deficient mice. CONCLUSION:Lesions in Cckbr-deficient mice occurred earlier in apatite orientation than in bone mass. Hence, bone apatite orientation may be a promising method for detecting hypochlorhydria-induced osteoporosis caused by PPI treatment and warrants urgent clinical applications. |
| Volume | 41(6) |
| Pages | 752-759 |
| Published | 2023-11-1 |
| DOI | 10.1007/s00774-023-01460-9 |
| PII | 10.1007/s00774-023-01460-9 |
| PMID | 37676507 |
| MeSH | Achlorhydria* Animals Apatites Bone Density Bone and Bones Femur / diagnostic imaging Mice Receptor, Cholecystokinin B* |
| Resource | |
| Mice | RBRC02289 |