論文 - 詳細
| RRC ID | 88545 |
|---|---|
| 著者 | Hanson CH, Henry B, Andhare P, Lin FJ, Pak H, Turner JS, Adams LJ, Liu T, Fremont DH, Ellebedy AH, Laidlaw BJ. |
| タイトル | CD62L expression marks a functionally distinct subset of memory B cells. |
| ジャーナル | Cell Rep |
| Abstract |
The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L+ memory B cell development. Bcl6 regulates memory B cell subset development through control of a network of genes, including Bcl2 and Zeb2. Overexpression of Zeb2 impairs the development of CD62L+ memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations. Together, these data indicate that CD62L expression marks functionally distinct memory B cell subsets. |
| 巻・号 | 42(12) |
| ページ | 113542 |
| 公開日 | 2023-12-26 |
| DOI | 10.1016/j.celrep.2023.113542 |
| PII | S2211-1247(23)01554-1 |
| PMID | 38060451 |
| PMC | PMC10842417 |
| MeSH | Animals Antigens / metabolism Humans Immunologic Memory L-Selectin Lymphocyte Activation Memory B Cells* Mice T-Lymphocyte Subsets* / metabolism Vaccination |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC09240 |