| RRC ID |
88545
|
| 著者 |
Hanson CH, Henry B, Andhare P, Lin FJ, Pak H, Turner JS, Adams LJ, Liu T, Fremont DH, Ellebedy AH, Laidlaw BJ.
|
| タイトル |
CD62L expression marks a functionally distinct subset of memory B cells.
|
| ジャーナル |
Cell Rep
|
| Abstract |
The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L+ memory B cell development. Bcl6 regulates memory B cell subset development through control of a network of genes, including Bcl2 and Zeb2. Overexpression of Zeb2 impairs the development of CD62L+ memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations. Together, these data indicate that CD62L expression marks functionally distinct memory B cell subsets.
|
| 巻・号 |
42(12)
|
| ページ |
113542
|
| 公開日 |
2023-12-26
|
| DOI |
10.1016/j.celrep.2023.113542
|
| PII |
S2211-1247(23)01554-1
|
| PMID |
38060451
|
| PMC |
PMC10842417
|
| MeSH |
Animals
Antigens / metabolism
Humans
Immunologic Memory
L-Selectin
Lymphocyte Activation
Memory B Cells*
Mice
T-Lymphocyte Subsets* / metabolism
Vaccination
|
| リソース情報 |
| 実験動物マウス |
RBRC09240 |
