論文 - 詳細
| RRC ID | 88572 |
|---|---|
| 著者 | Izumi-Mishima Y, Tsutsumi R, Shiuchi T, Fujimoto S, Taniguchi M, Sugiuchi M, Tsutsumi M, Okamatsu-Ogura Y, Yoneshiro T, Kuroda M, Nomura K, Sakaue H. |
| タイトル | Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice. |
| ジャーナル | Elife |
| Abstract |
Endotherms increase the rate of metabolism in metabolic organs as one strategy to cope with a decline in the temperature of the external environment. However, an additional major contributor to maintenance of body temperature in a cold environment is contraction-based thermogenesis in skeletal muscle. Here, we show that impairment of hind limb muscle contraction by cast immobilization induced a loss of function of skeletal muscle and activated brown adipose tissue (BAT) thermogenesis as a compensatory mechanism. BAT utilizes free branched-chain amino acids (BCAAs) derived from skeletal muscle as an energy substrate for thermogenesis, and interleukin-6 released by skeletal muscle stimulates BCAAs production in muscle for support of BAT thermogenesis. Additionally, this thermoregulatory system between BAT and skeletal muscle may also play an important role in response to cold temperatures or acute stress. Our findings suggest that BAT and skeletal muscle cooperate to maintain body temperature in endotherms. |
| 巻・号 | 13 |
| 公開日 | 2025-10-27 |
| DOI | 10.7554/eLife.99982 |
| PII | 99982 |
| PMID | 41143503 |
| PMC | PMC12558653 |
| MeSH | Adipose Tissue, Brown* / metabolism Adipose Tissue, Brown* / physiology Amino Acids, Branched-Chain / metabolism Animals Interleukin-6 / metabolism Male Mice Mice, Inbred C57BL Muscle, Skeletal* / metabolism Muscle, Skeletal* / physiology Thermogenesis* |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC04918 |