論文 - 詳細
| RRC ID | 88582 |
|---|---|
| 著者 | Shintaro Otsuka, Yuriko Nakamura, Aya Ito-Ishida, Kunimichi Suzuki, Ayako Ishikawa, Keiko Matsuda, Shigetomo Suyama, Anis Contractor, Michisuke Yuzaki |
| タイトル | Operant House: A Versatile Open-Source Platform for Automated Operant Conditioning Testing of Mice in Home Cages |
| Abstract |
Operant conditioning is a valuable method for studying cognitive functions, yet its adoption is limited by low throughput, labor intensity, and high costs. Here, we developed “Operant House,” a low-cost, programmable device featuring a touchscreen, retractable levers, and a water reward port, designed for flexible, automated operant conditioning tasks. To validate its utility, we implemented two protocols to assess working memory in mice: a delayed non-match-to-position test and a two-choice spatial discrimination test. Using these protocols, we examined a mouse model of Alzheimer’s disease carrying familial Alzheimer’s disease-associated amyloid precursor protein mutations. Results revealed significant working memory deficits as early as 5 months of age. These findings highlight the Operant House as a cost-effective, high-throughput platform for evaluating higher cognitive functions in mice, offering an accessible tool for investigating models of neurological and neuropsychiatric disorders. |
| DOI | 10.1101/2025.01.24.634815 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.0 |
| リソース情報 | |
| 実験動物マウス | RBRC06344 |