| RRC ID |
88696
|
| Author |
Fan S, Cai X, Cui W, Ma P, Wu M, Guo J, Zhang Y, Xuan K, Li Z.
|
| Title |
Restoration of gut integrity by Bacteroides acidifaciens in water-deprived conditions.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Water scarcity exerts profound physiological impacts, yet its effects on intestinal microbiota-barrier crosstalk remain poorly understood. This study investigates water-deprivation-induced gut dysbiosis and identifies Bacteroides acidifaciens (B.acidifaciens) as a critical mediator of epithelial barrier resilience. Using a murine model of graded water restriction, we observed colon shortening, villus atrophy, goblet cell loss, and barrier disruption correlated with water-deprivation severity. Oral supplementation of B.acidifaciens restored colonic architecture, enhanced mucin secretion, and ameliorated barrier dysfunction in water-deprived mice. Mechanistically, B.acidifaciens maintained barrier homeostasis by directly stimulating mucus production in intestinal epithelial cells and upregulating the expression of tight junction proteins. These findings establish B.acidifaciens as a critical species in mitigating water-deprivation-induced colon injury and advance our understanding of microbiota-directed interventions for dehydration-associated gastrointestinal disorders.
|
| Volume |
767
|
| Pages |
151917
|
| Published |
2025-6-30
|
| DOI |
10.1016/j.bbrc.2025.151917
|
| PII |
S0006-291X(25)00631-X
|
| PMID |
40318377
|
| MeSH |
Animals
Bacteroides* / physiology
Colon / microbiology
Colon / pathology
Dysbiosis / microbiology
Gastrointestinal Microbiome* / physiology
Intestinal Mucosa / metabolism
Intestinal Mucosa / microbiology
Intestinal Mucosa / pathology
Male
Mice
Mice, Inbred C57BL
Water / metabolism
|
| Resource |
| General Microbes |
JCM10556 |
