論文 - 詳細
| RRC ID | 88701 |
|---|---|
| 著者 | De Padua JC, Kikuchi T, Sakakibara F, De Leon AM, Bungihan ME, Ueno K, Dela Cruz TEE, Ishihara A. |
| タイトル | Novel compound, pleuropyronine, and other polyketides isolated from the edible mushroom Pleurotus ostreatus suppress bacterial biofilm formation. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
An increase in the number of drug-resistant microbes is a major threat to human health. Bacterial drug resistance is mostly mediated by biofilm formation. In this study, the culture filtrate from the edible mushroom, Pleurotus ostreatus, was fractionated to isolate compounds that inhibit the biofilm formation of six pathogenic bacteria. Notably, we isolated compounds 1-6 using bioassay-guided chromatographic separations. Spectroscopic and X-ray diffraction analyses identified 1 as a novel fused bicyclic pyrone-furan, named pleuropyronine, whereas 2-6 were known polyketides. Pleuropyronine inhibited biofilm formation in four Gram-negative bacteria, with IC50 values ranging from 5.4 to 8.7 µg/mL, whereas 2-6 exhibited IC50 values between 1.0 and 5.3 µg/mL against five bacteria. Additionally, pleuropyronine bioactivity was confirmed by the inhibition of exopolysaccharide and biofilm formation induced by C6-homoserine lactone. Thus, this may serve as a pioneering study on the pharmacological potential of isolated compounds, offering valuable insights for future research. |
| 巻・号 | 89(1) |
| ページ | 11-21 |
| 公開日 | 2024-12-23 |
| DOI | 10.1093/bbb/zbae148 |
| PII | 7826787 |
| PMID | 39424595 |
| MeSH | Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification Anti-Bacterial Agents / pharmacology Biofilms* / drug effects Biofilms* / growth & development Microbial Sensitivity Tests Pleurotus* / chemistry Polyketides* / chemistry Polyketides* / isolation & purification Polyketides* / pharmacology Pyrones / chemistry Pyrones / isolation & purification Pyrones / pharmacology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM5803 JCM2151 JCM1662 JCM6841 JCM5962 JCM1649 |