論文 - 詳細
| RRC ID | 88716 |
|---|---|
| 著者 | Zhang D, Zou Y, Shi Y, Zhang J, Liu J, Wu G, Zhang J, Gao Y, Chen M, Li YX. |
| タイトル | Systematically investigating and identifying bacteriocins in the human gut microbiome. |
| ジャーナル | Cell Genom |
| Abstract |
Human gut microbiota produces unmodified bacteriocins, natural antimicrobial peptides that protect against pathogens and regulate host physiology. However, current bioinformatic tools limit the comprehensive investigation of bacteriocins' biosynthesis, obstructing research into their biological functions. Here, we introduce IIBacFinder, a superior analysis pipeline for identifying unmodified class II bacteriocins. Through large-scale bioinformatic analysis and experimental validation, we demonstrate their widespread distribution across the bacterial kingdom, with most being habitat specific. Analyzing over 280,000 bacterial genomes, we reveal the diverse potential of human gut bacteria to produce these bacteriocins. Guided by meta-omics analysis, we synthesized 26 hypothetical bacteriocins from gut commensal species, with 16 showing antibacterial activities. Further ex vivo tests show minimal impact of narrow-spectrum bacteriocins on human fecal microbiota. Our study highlights the huge biosynthetic potential of unmodified bacteriocins in the human gut, paving the way for understanding their biological functions and health implications. |
| 巻・号 | 5(11) |
| ページ | 100983 |
| 公開日 | 2025-11-12 |
| DOI | 10.1016/j.xgen.2025.100983 |
| PII | S2666-979X(25)00239-3 |
| PMID | 40902606 |
| PMC | PMC12648112 |
| MeSH | Bacteria* / chemistry Bacteria* / classification Bacteria* / genetics Bacteriocins* / analysis Gastrointestinal Microbiome* Genome, Bacterial Humans Metagenomics Software |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM7512 JCM2410 JCM18283 |