Reference - Detail
| RRC ID | 88718 |
|---|---|
| Author | Zha X, Liu X, Wei M, Huang H, Cao J, Liu S, Bian X, Zhang Y, Xiao F, Xie Y, Wang W, Zhang C. |
| Title | Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis. |
| Journal | Cell Metab |
| Abstract |
Alzheimer's disease (AD) is a pervasive neurodegenerative disorder, and new approaches for its prevention and therapy are critically needed. Here, we elucidate a gut-microbiome-brain axis that offers actionable perspectives for achieving this objective. Using the 5xFAD mouse model, we identify increased Clostridium abundance and decreased Bacteroides abundance as key features associated with β-amyloid (Aβ) burden. Treatment with Bacteroides ovatus, or its associated metabolite lysophosphatidylcholine (LPC), significantly reduces Aβ load and ameliorates cognitive impairment. Mechanistically, LPC acts through the orphan receptor GPR119, inhibiting ACSL4 expression, thereby suppressing ferroptosis and ameliorating AD pathologies. Analysis of fecal and serum samples from individuals with AD also reveals diminished levels of Bacteroides and LPC. This study thus identifies a B.ovatus-triggered pathway regulating AD pathologies and indicates that the use of single gut microbiota, metabolite, or small molecule compound may complement current prevention and treatment approaches for AD. |
| Volume | 37(1) |
| Pages | 169-186.e9 |
| Published | 2025-1-7 |
| DOI | 10.1016/j.cmet.2024.10.006 |
| PII | S1550-4131(24)00402-9 |
| PMID | 39510074 |
| MeSH | Alzheimer Disease* / drug therapy Alzheimer Disease* / metabolism Alzheimer Disease* / microbiology Alzheimer Disease* / pathology Amyloid beta-Peptides / metabolism Animals Disease Models, Animal Female Ferroptosis* / drug effects Gastrointestinal Microbiome* / drug effects Humans Lysophosphatidylcholines* / metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic |
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オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 43 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| General Microbes | JCM5826 JCM13471 JCM5827 |