論文 - 詳細
| RRC ID | 88765 |
|---|---|
| 著者 | Berkhout MD, Ioannou A, Kavanal Jayaprakash Y, Plugge CM, Belzer C. |
| タイトル | Milk and mucin glycans orchestrate a synthetic infant gut microbiota structure. |
| ジャーナル | FEMS Microbiol Ecol |
| Abstract |
Glycans are crucial for infant gut microbiota development. Human milk contains prebiotic human milk oligosaccharides (HMOs) that stimulate gut microbes. Simultaneously, the glycan-rich mucus layer develops and attracts mucin glycan-degrading bacteria. As HMOs and mucin are degraded by homologous enzymes, bacterial glycan-degrading abilities overlap. However, less is known about how infant gut microbial communities form when both types of glycans are available. To study this, we created a synthetic community with specialist glycan degraders and cross-feeders from the infant gut (BabyBac). We evaluated it in different in vitro conditions including combinations of diet-derived [HMOs, galactooligosaccharides (GOS), and fructooligosaccharides (FOS)] and mucus glycans. Glycan combinations significantly affected the community composition and metabolic output. The glycan type affected the overall community, with mucin and HMOs being the top drivers of variation. HMOs favoured glycan degraders and cross-feeders, whereas mucin glycan degrader Akkermansia muciniphila was outcompeted. Conversely, when mucin was present, A. muciniphila thrived. Addition of mucin monomers and 2'-FL to GOS/FOS did not reinstate A. muciniphila abundance. This suggests that A. muciniphila cannot compete with infant-related bacteria without the complete mucin structure. Overall, our findings suggest that the interplay between dietary and mucus glycans creates niche differentiation in the infant gut microbiota. |
| 巻・号 | 101(8) |
| 公開日 | 2025-7-14 |
| DOI | 10.1093/femsec/fiaf069 |
| PII | 8173770 |
| PMID | 40560164 |
| PMC | PMC12268331 |
| MeSH | Akkermansia Bacteria / classification Bacteria / genetics Bacteria / metabolism Gastrointestinal Microbiome* / physiology Humans Infant Milk, Human* / chemistry Milk, Human* / metabolism Mucins* / metabolism Oligosaccharides / metabolism Polysaccharides* / metabolism Prebiotics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 2.2 |
| リソース情報 | |
| 一般微生物 | JCM1254 JCM1471 |