| RRC ID |
88804
|
| 著者 |
Ma C, Zheng X, Zhang Q, Renaud SJ, Yu H, Xu Y, Chen Y, Gong J, Cai Y, Hong Y, Li H, Liao Q, Guo Y, Kang L, Xie Z.
|
| タイトル |
A postbiotic exopolysaccharide synergizes with Lactobacillus acidophilus to reduce intestinal inflammation in a mouse model of colitis.
|
| ジャーナル |
Int J Biol Macromol
|
| Abstract |
Ulcerative colitis (UC) is an inflammatory bowel disease marked by gut inflammation and microbial dysbiosis. Exopolysaccharides (EPS) from probiotic bacteria have been shown to regulate microbial composition and metabolism, but their role in promoting probiotic growth and alleviating inflammation in UC remains unclear. Here, we investigate BLEPS-1, a novel EPS derived from Bifidobacterium longum subsp. longum XZ01, for its ability to promote the growth of Lactobacillus strains. We then tested a synbiotic formulation of BLEPS-1 and L. acidophilus in a DSS-induced UC mouse model. The combination of BLEPS-1 and L. acidophilus alleviated DSS-induced intestinal inflammation, outperforming either component alone. Administration of BLEPS-1 decreased the proportion of M1 macrophages in the intestine, while M2 macrophages were more abundant following L. acidophilus treatment. Together, BLEPS-1 and L. acidophilus synergistically modulated macrophage polarization toward the M2-type. Administration of BLEPS-1 and L. acidophilus together modulated gut microbiota composition and altered the gut metabolic profile, with BLEPS-1 and L. acidophilus promoting metabolism of short-chain fatty acids and aromatic amino acids, respectively. Our study identified a novel synbiotic formulation with potent immunomodulatory and metabolic activity, laying the groundwork for a promising therapeutic strategy to treat intestinal inflammatory diseases such as colitis.
|
| 巻・号 |
291
|
| ページ |
138931
|
| 公開日 |
2025-2-1
|
| DOI |
10.1016/j.ijbiomac.2024.138931
|
| PII |
S0141-8130(24)09742-3
|
| PMID |
39732236
|
| MeSH |
Animals
Colitis* / chemically induced
Colitis* / drug therapy
Colitis* / microbiology
Colitis* / pathology
Disease Models, Animal
Gastrointestinal Microbiome / drug effects
Inflammation / drug therapy
Lactobacillus acidophilus*
Macrophages / drug effects
Male
Mice
Mice, Inbred C57BL
Polysaccharides, Bacterial* / pharmacology
Probiotics* / pharmacology
Synbiotics / administration & dosage
|
| リソース情報 |
| 一般微生物 |
JCM1112 |
