| RRC ID |
88936
|
| Author |
Kudo K, Nishimura T, Miyako K, Suenaga H, Shin-Ya K.
|
| Title |
A new cannabigerolic acid derivative and its unprenylated precursor produced through the reconstitution of cannabinoid biosynthesis in Streptomyces.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
A new derivative of cannabigerolic acid, designated as iso-cannabigerolic acid (iso-CBGA), a member of the cannabinoid family, and its precursor iso-olivetolic acid (iso-OA) were discovered from the culture of the engineered Streptomyces avermitilis heterologously expressing the genes responsible for cannabigerolic acid biosynthesis. Structural determination revealed an iso-pentyl moiety, which may arise from the biosynthetic precursor pool present in S. avermitilis. We describe herein the culture, isolation, structure determination and antibacterial activities of iso-CBGA and iso-OA.
|
| Volume |
78(2)
|
| Pages |
126-130
|
| Published |
2025-1-1
|
| DOI |
10.1038/s41429-024-00793-5
|
| PII |
10.1038/s41429-024-00793-5
|
| PMID |
39627321
|
| MeSH |
Anti-Bacterial Agents* / biosynthesis
Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Benzoates
Cannabinoids* / biosynthesis
Cannabinoids* / chemistry
Cannabinoids* / metabolism
Molecular Structure
Streptomyces* / genetics
Streptomyces* / metabolism
|
| Resource |
| General Microbes |
JCM36731 |
