論文 - 詳細
| RRC ID | 88936 |
|---|---|
| 著者 | Kudo K, Nishimura T, Miyako K, Suenaga H, Shin-Ya K. |
| タイトル | A new cannabigerolic acid derivative and its unprenylated precursor produced through the reconstitution of cannabinoid biosynthesis in Streptomyces. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
A new derivative of cannabigerolic acid, designated as iso-cannabigerolic acid (iso-CBGA), a member of the cannabinoid family, and its precursor iso-olivetolic acid (iso-OA) were discovered from the culture of the engineered Streptomyces avermitilis heterologously expressing the genes responsible for cannabigerolic acid biosynthesis. Structural determination revealed an iso-pentyl moiety, which may arise from the biosynthetic precursor pool present in S. avermitilis. We describe herein the culture, isolation, structure determination and antibacterial activities of iso-CBGA and iso-OA. |
| 巻・号 | 78(2) |
| ページ | 126-130 |
| 公開日 | 2025-1-1 |
| DOI | 10.1038/s41429-024-00793-5 |
| PII | 10.1038/s41429-024-00793-5 |
| PMID | 39627321 |
| MeSH | Anti-Bacterial Agents* / biosynthesis Anti-Bacterial Agents* / chemistry Anti-Bacterial Agents* / pharmacology Benzoates Cannabinoids* / biosynthesis Cannabinoids* / chemistry Cannabinoids* / metabolism Molecular Structure Streptomyces* / genetics Streptomyces* / metabolism |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM36731 |