| RRC ID |
88959
|
| 著者 |
Ono N, Ito Y, Aoki S, Shiohama A, Sasaki T, Kurokawa R, Suda W, Amagai M, Kubo A.
|
| タイトル |
Microbial dysbiosis and foot odor in Nagashima-type palmoplantar keratosis: Improvement with topical benzoyl peroxide.
|
| ジャーナル |
J Invest Dermatol
|
| Abstract |
Nagashima-type palmoplantar keratosis (also referred to as SERPINB7-related palmoplantar epidermal differentiation disorder) is the most common form of palmoplantar keratoderma in East Asia. It is characterized by erythematous hyperkeratosis, palmoplantar hyperhidrosis, and a distinctive foot odor that significantly impairs QOL. In this study, we aimed to clarify the etiology of this odor by investigating the plantar microbiome and evaluating the therapeutic effects of topical benzoyl peroxide. Compared with healthy controls, individuals with Nagashima-type palmoplantar keratosis exhibited significantly higher objective odor scores; increased bacterial load, especially in the intertoe area; and reduced microbial diversity. Corynebacterium and Staphylococcus were the predominant dysbiotic flora species. The topical application of benzoyl peroxide significantly reduced foot odor and bacterial load; increased microbial diversity; and selectively decreased Corynebacterium abundance, particularly that of C tuberculostearicum. These changes correlate with the species-specific susceptibility of skin-resident bacteria to benzoyl peroxide. Our findings suggest that microbial dysbiosis, especially the overgrowth of Corynebacterium species, is central to the pathogenesis of foot odor in Nagashima-type palmoplantar keratosis. Topical benzoyl peroxide is a promising therapeutic intervention for mitigating dysbiosis and its associated foot odor. This study highlights the potential of microbiome-targeted therapies for symptom relief in inherited skin disorders such as Nagashima-type palmoplantar keratosis.
|
| 巻・号 |
146(6)
|
| ページ |
1586-1595.e5
|
| 公開日 |
2026-6-1
|
| DOI |
10.1016/j.jid.2025.11.011
|
| PII |
S0022-202X(25)03614-0
|
| PMID |
41338335
|
| MeSH |
Administration, Topical
Adult
Benzoyl Peroxide* / administration & dosage
Benzoyl Peroxide* / therapeutic use
Corynebacterium / drug effects
Corynebacterium / isolation & purification
Dermatologic Agents* / administration & dosage
Dysbiosis* / drug therapy
Dysbiosis* / microbiology
Female
Humans
Keratoderma, Palmoplantar* / complications
Keratoderma, Palmoplantar* / drug therapy
Keratoderma, Palmoplantar* / microbiology
Male
Middle Aged
Odorants* / prevention & control
Skin Microbiome
Treatment Outcome
Young Adult
|
| リソース情報 |
| 一般微生物 |
JCM2414
JCM13389 |
