論文 - 詳細
| RRC ID | 89021 |
|---|---|
| 著者 | Hosomi K, Maruyama S, Matsuoka T, Furuta M, Tojima Y, Uchiyama K, Morita M, Kawashima H, Kobayashi T, Kunisawa J. |
| タイトル | Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii. |
| ジャーナル | Microbiome |
| Abstract |
BACKGROUND:The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health. RESULTS:We identified a unique interaction between the pathobiont Fusobacterium varium and the symbiont Faecalibacterium prausnitzii, both members of the gut microbial community; their interaction is driven by metabolites and direct cell-to-cell contact. Growth of F. varium was inhibited in the presence of F. prausnitzii because of a decrease in pH and an increase in β-hydroxybutyric acid. Conversely, the growth of F. prausnitzii was promoted in the presence of F. varium, likely via direct contact. CONCLUSIONS:These findings highlight the importance of metabolite-driven interactions and direct contact in shaping gut microbial communities and emphasize the potential of interactions between F. prausnitzii and F. varium in influencing gut health. Video Abstract. |
| 巻・号 | 13(1) |
| ページ | 175 |
| 公開日 | 2025-7-28 |
| DOI | 10.1186/s40168-025-02168-w |
| PII | 10.1186/s40168-025-02168-w |
| PMID | 40721806 |
| PMC | PMC12302451 |
| MeSH | Faecalibacterium prausnitzii* / growth & development Faecalibacterium prausnitzii* / metabolism Faecalibacterium prausnitzii* / physiology Feces / microbiology Fusobacterium* / growth & development Fusobacterium* / metabolism Fusobacterium* / physiology Gastrointestinal Microbiome* Humans Hydrogen-Ion Concentration Microbial Interactions* Symbiosis |
| リソース情報 | |
| 一般微生物 | JCM6320 JCM31915 JCM5826 JCM31267 JCM1217 JCM33894 |