論文 - 詳細
| RRC ID | 89040 |
|---|---|
| 著者 | Shimizu H, Miyamoto J, Hisa K, Ohue-Kitano R, Takada H, Yamano M, Nishida A, Sasahara D, Masujima Y, Watanabe K, Nishikawa S, Takahashi S, Ikeda T, Nakajima Y, Yoshida N, Matsuzaki C, Kageyama T, Hayashi I, Matsuki A, Akashi R, Kitahama S, Ueyama M, Murakami T, Inuki S, Irie J, Satoh-Asahara N, Toju H, Mori H, Nakaoka S, Yamashita T, Toyoda A, Yamamoto K, Ohno H, Katayama T, Itoh H, Kimura I. |
| タイトル | Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides. |
| ジャーナル | Nat Commun |
| Abstract |
Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) -short-chain fatty acid (SCFA) -carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. S. salivarius abundance was significantly decreased in human donors with obesity compared with that in healthy donors, and the EPS-SCFA bacterial carbohydrate metabolic process was attenuated. Our findings reveal an important mechanism by which host-commensal interactions in glycometabolism affect energy regulation, suggesting an approach for preventing lifestyle-related diseases via prebiotics and probiotics by targeting bacteria and EPS metabolites. |
| 巻・号 | 16(1) |
| ページ | 1145 |
| 公開日 | 2025-1-29 |
| DOI | 10.1038/s41467-025-56470-0 |
| PII | 10.1038/s41467-025-56470-0 |
| PMID | 39880823 |
| PMC | PMC11779931 |
| MeSH | Adult Animals Fatty Acids, Volatile / metabolism Female Gastrointestinal Microbiome* / physiology Humans Male Mice Mice, Inbred C57BL Obesity* / metabolism Obesity* / microbiology Obesity* / prevention & control Polysaccharides, Bacterial* / metabolism Prebiotics Streptococcus* / metabolism Sucrose* / metabolism |
| リソース情報 | |
| 一般微生物 | JCM30893 JCM15631 JCM9498 JCM13471 JCM13265 JCM5824 JCM9496 JCM5827 JCM5828 JCM5826 JCM33112 JCM33114 JCM33116 JCM1275 JCM10602 JCM1255 JCM1192 JCM1194 JCM1222 JCM1217 JCM1200 JCM1205 JCM1395 JCM14655 JCM1291 JCM1397 JCM31500 JCM1298 JCM6567 JCM10188 JCM6421 JCM10261 JCM1134 JCM1131 JCM2012 JCM1149 JCM1112 JCM1136 JCM5805 JCM6124 JCM5825 JCM13406 JCM9497 JCM5705 JCM17834 JCM5707 JCM1401 |