| RRC ID |
89042
|
| 著者 |
Zhao F, Zou Z, Liu Z, Wang J, Wu Y, Zhang J, Liu Q, Liang W, Yao J, Jiang X, Routledge MN, Khan A, Zhang H, Qiu J, Chen C.
|
| タイトル |
A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid.
|
| ジャーナル |
Nat Commun
|
| Abstract |
The effects of dietary amino acid restriction on obesity may be related to the gut microbiome, but its role and mechanism in lysine-restricted diet (LRD) on childhood obesity is largely undefined. Herein, we show that blood lysine levels are elevated in children with obesity compared to healthy controls. Using young mice, we show that LRD ameliorates obesity via gut microbiota modulation. We further identify Parabacteroides goldsteinii (P. goldsteinii) as a candidate contributor and validate that its supplementation reduces obesity phenotype. Metabolomics reveals that P. goldsteinii increases 1,4-methylimidazoleacetic acid (MIAA), a metabolite linked to decreased body weight in animal models. Mechanistically, we show that MIAA inhibits the expression of the demethylase FTO, leading to increased m6A modifications on Slc2a4 mRNA via the reader protein YTHDC1. Collectively, these findings suggest a role for P. goldsteinii and its metabolite MIAA on LRD-mediated obesity reduction, potentially via the FTO-SLC2A4 axis to restrict adipose tissue expansion.
|
| 巻・号 |
16(1)
|
| ページ |
9953
|
| 公開日 |
2025-11-12
|
| DOI |
10.1038/s41467-025-64892-z
|
| PII |
10.1038/s41467-025-64892-z
|
| PMID |
41224764
|
| PMC |
PMC12612160
|
| MeSH |
Adipose Tissue / metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism
Animals
Child
Female
Gastrointestinal Microbiome / physiology
Humans
Imidazoles* / metabolism
Lysine* / blood
Lysine* / deficiency
Male
Mice
Mice, Inbred C57BL
Obesity* / blood
Obesity* / diet therapy
Obesity* / metabolism
Obesity* / microbiology
|
| リソース情報 |
| 一般微生物 |
JCM13446 |
