論文 - 詳細
| RRC ID | 89104 |
|---|---|
| 著者 | Ikeda M, Haruhara K, Maruyama Y, Tanaka N, Kusanagi R, Sakamaki Y, Hagiwara H, Yokoo T. |
| タイトル | Peritoneal Lavage With Low GDP Neutral pH PD Solution Reduces Mortality and Severity in a Lethal Peritonitis Model. |
| ジャーナル | Ther Apher Dial |
| Abstract |
INTRODUCTION:The efficacy of peritoneal lavage monotherapy using PD solution for severe peritonitis remains unproven. METHODS:We evaluated the effects of 3-times and 6-times lavage using low GDP neutral PD solution on a Methicillin-sensitive Staphylococcus aureus (MSSA) lethal peritonitis model rats without antibiotic use. Changes in effluent viable bacteria numbers dependent on lavage frequency were determined in a further 10 rats. RESULTS:Compared to the lethal peritonitis model without lavage, both 3-times and 6-times lavage significantly reduced 24-h mortality, effluent FDP and creatinine concentrations. Furthermore, 6-times lavage significantly prevented the rough fur development, intraabdominal adhesion, and pus formation which developed in both the 0-times and 3-times lavage groups. The effluent viable bacterial counts showed significant step-ladder decreases with an increasing number of the lavages. CONCLUSION:We demonstrated for the first time that lavage monotherapy using PD solution reduces mortality and severity in a lethal peritonitis model by rapidly eliminating bacteria without antibiotic use. |
| 巻・号 | 29(5) |
| ページ | 752-759 |
| 公開日 | 2025-10-1 |
| DOI | 10.1111/1744-9987.70061 |
| PMID | 40633943 |
| PMC | PMC12411685 |
| MeSH | Animals Dialysis Solutions* / administration & dosage Dialysis Solutions* / chemistry Disease Models, Animal Hydrogen-Ion Concentration Male Peritoneal Lavage* / methods Peritonitis* / microbiology Peritonitis* / mortality Peritonitis* / therapy Rats Severity of Illness Index Staphylococcal Infections* / mortality Staphylococcal Infections* / therapy Staphylococcus aureus / isolation & purification |
| リソース情報 | |
| 一般微生物 | JCM2413 |