| RRC ID |
89120
|
| Author |
Podnar E, Dendinovic K, Danevčič T, Lories B, Kovačec E, Steenackers H, Mandic-Mulec I.
|
| Title |
Bacillus subtilis ensures high spore quality in competition with Salmonella Typhimurium via the SigB-dependent pathway.
|
| Journal |
ISME J
|
| Abstract |
The interactions between beneficial bacteria and pathogens are understudied. Here we investigate the interactions between the probiotic strain Bacillus subtilis PS-216 and the pathogen Salmonella Typhimurium SL1344. We show here that the sporulation of B. subtilis is impaired when it competes with S. Typhimurium in a nutrient-depleted medium. The sporulation impairment in B. subtilis is mediated by the sigma factor B (SigB)-dependent general stress response, as the ΔsigB mutant remains blind to manipulative cues from S. Typhimurium. Furthermore, we show that decreased sporulation frequency in B. subtilis depends on cell-cell contact between the two species involving the S. Typhimurium Type VI Secretion System, whereas B. subtilis uses the SigB-dependent response to trade spore quantity for higher spore quality.
|
| Volume |
19(1)
|
| Published |
2025-1-2
|
| DOI |
10.1093/ismejo/wraf052
|
| PII |
8082934
|
| PMID |
40098255
|
| PMC |
PMC11994997
|
| MeSH |
Bacillus subtilis* / genetics
Bacillus subtilis* / growth & development
Bacillus subtilis* / physiology
Bacterial Proteins* / genetics
Bacterial Proteins* / metabolism
Gene Expression Regulation, Bacterial
Microbial Interactions*
Salmonella typhimurium* / genetics
Salmonella typhimurium* / growth & development
Salmonella typhimurium* / physiology
Sigma Factor* / genetics
Sigma Factor* / metabolism
Spores, Bacterial* / growth & development
Spores, Bacterial* / physiology
|
| Resource |
| Prokaryotes B. subtilis |
|
