Reference - Detail
| RRC ID | 89183 |
|---|---|
| Author | Tanaka R, Hara Y, Sato K, Kohatsu S, Murakami H, Higuchi T, Awasaki T, Kondo S, Toyoda A, Kamikouchi A, Yamamoto D. |
| Title | Cross-species implementation of an innate courtship behavior by manipulation of the sex-determinant gene. |
| Journal | Science |
| Abstract |
In accepting a courting male, Drosophila subobscura females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in D. melanogaster. By clonal activation of neurons expressing the male-determinant FruM, we identified insulin-like peptide-producing cells (IPCs) and their putative postsynaptic targets, proboscis-innervating motoneurons, as those critical for gift giving. We demonstrate that loss of FruM from D. subobscura IPCs abrogates neurite extension and gift giving, whereas FruM overexpression in their D. melanogaster counterparts induces overgrowth of neurites that harbor functional synapses, culminating in increased regurgitation. We suggest that the acquisition of FruM expression by IPCs was a key event occurring in an ancestral D. subobscura that conferred a latent capability to perform nuptial gift giving. |
| Volume | 389(6761) |
| Pages | 747-752 |
| Published | 2025-8-14 |
| DOI | 10.1126/science.adp5831 |
| PMID | 40811529 |
| MeSH | Animals Courtship* Drosophila* / genetics Drosophila* / physiology Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila Proteins* / physiology Drosophila melanogaster / genetics Drosophila melanogaster / physiology Female Male Motor Neurons / physiology Nerve Tissue Proteins* / genetics Nerve Tissue Proteins* / metabolism Nerve Tissue Proteins* / physiology Sexual Behavior, Animal* Synapses / physiology Transcription Factors* / genetics Transcription Factors* / metabolism Transcription Factors* / physiology |
| IF | 41.846 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 172 |
| Altmetric score changes over past 6months | 61.0 |
| Resource | |
| Drosophila | |