| RRC ID |
89208
|
| Author |
Getzke F, Wang L, Chesneau G, Böhringer N, Mesny F, Denissen N, Wesseler H, Adisa PT, Marner M, Schulze-Lefert P, Schäberle TF, Hacquard S.
|
| Title |
Physiochemical interaction between osmotic stress and a bacterial exometabolite promotes plant disease.
|
| Journal |
Nat Commun
|
| Abstract |
Various microbes isolated from healthy plants are detrimental under laboratory conditions, indicating the existence of molecular mechanisms preventing disease in nature. Here, we demonstrated that application of sodium chloride (NaCl) in natural and gnotobiotic soil systems is sufficient to induce plant disease caused by an otherwise non-pathogenic root-derived Pseudomonas brassicacearum isolate (R401). Disease caused by combinatorial treatment of NaCl and R401 triggered extensive, root-specific transcriptional reprogramming that did not involve down-regulation of host innate immune genes, nor dampening of ROS-mediated immunity. Instead, we identified and structurally characterized the R401 lipopeptide brassicapeptin A as necessary and sufficient to promote disease on salt-treated plants. Brassicapeptin A production is salt-inducible, promotes root colonization and transitions R401 from being beneficial to being detrimental on salt-treated plants by disturbing host ion homeostasis, thereby bolstering susceptibility to osmolytes. We conclude that the interaction between a global change stressor and a single exometabolite from a member of the root microbiome promotes plant disease in complex soil systems.
|
| Volume |
15(1)
|
| Pages |
4438
|
| Published |
2024-5-28
|
| DOI |
10.1038/s41467-024-48517-5
|
| PII |
10.1038/s41467-024-48517-5
|
| PMID |
38806462
|
| PMC |
PMC11133316
|
| MeSH |
Arabidopsis / drug effects
Arabidopsis / genetics
Arabidopsis / metabolism
Arabidopsis / microbiology
Lipopeptides / metabolism
Lipopeptides / pharmacology
Osmotic Pressure*
Plant Diseases* / microbiology
Plant Roots* / metabolism
Plant Roots* / microbiology
Pseudomonas* / genetics
Pseudomonas* / metabolism
Sodium Chloride / metabolism
Sodium Chloride / pharmacology
Soil Microbiology
|
| Resource |
| Lotus / Glycine |
Gifu B-129 |
