論文 - 詳細
| RRC ID | 89246 |
|---|---|
| 著者 | Kaneda T, Matsuda-Imai N, Kosako H, Shoji K, Suzuki MG, Suzuki Y, Kiuchi T, Katsuma S. |
| タイトル | The Masc-PSI complex directly induces male-type doublesex splicing in silkworms. |
| ジャーナル | Commun Biol |
| Abstract |
The WZ sex determination system is found in a diverse range of animals, including lepidopteran insects. In the silkworm Bombyx mori, the masculinizing protein Masculinizer (BmMasc) induces the production of the male-type Bombyx mori doublesex (BmdsxM), which is the master genetic switch of B. mori sex differentiation. However, the molecular mechanism through which BmMasc transduces the masculinizing signal to the BmdsxM production remains unknown. Here, we show that BmMasc physically interacts with Bombyx mori P-element somatic inhibitor (BmPSI), a RNA binding protein required for BmdsxM expression. Knockdown experiments indicate that BmPSI is essential for the masculinizing activity of BmMasc. RNA immunoprecipitation experiments also reveal that BmMasc-containing protein complex is associated with female-specific regions of Bmdsx pre-mRNA. Taken together, our findings show that the BmMasc-BmPSI protein complex binds to female-specific Bmdsx regions, inducing exon skipping, and thereby promoting BmdsxM expression in B. mori males. |
| 巻・号 | 8(1) |
| ページ | 927 |
| 公開日 | 2025-6-14 |
| DOI | 10.1038/s42003-025-08350-y |
| PII | 10.1038/s42003-025-08350-y |
| PMID | 40517142 |
| PMC | PMC12167360 |
| MeSH | Animals Bombyx* / genetics Bombyx* / metabolism DNA-Binding Proteins Female Insect Proteins* / genetics Insect Proteins* / metabolism Male RNA Splicing* RNA-Binding Proteins* / genetics RNA-Binding Proteins* / metabolism Sex Determination Processes Sex Differentiation / genetics |
| IF | 4.165 |
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| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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