| RRC ID |
89366
|
| Author |
Khatun ML, Triningsih DW, Oku N, Nogawa T, Arai N, Takahashi K, Matsuura N, Ito K, Iwata C, Saito S, Meguro Y, Enomoto M, Arai MA, Igarashi Y.
|
| Title |
Catenulamide A, an acylated tripeptide containing 5-methoxy-L-kynurenine lactam from an actinomycete of the genus Catenuloplanes.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
A novel linear acylated tripeptide, catenulamide A (1), was isolated from a culture extract of Catenuloplanes sp. RD061694. Comprehensive spectroscopic analyses coupled with Marfey's analysis established that 1 comprised n-butyric acid, N-methyl-L-isoleucine, L-valine, and a lactamized new amino acid, 5-methoxy-L-kynurenine lactam. Compound 1 exhibited dual PPARα and PPARγ agonist activities in a luciferase reporter gene assay and anti-inflammatory potential by inhibiting nitric oxide production in lipopolysaccharide-stimulated murine macrophages with an IC50 value of 29 µM. Furthermore, 1 at 1 μM promoted radicle elongation of germinated lettuce seeds by 40% compared to vehicle-treated seeds.
|
| Published |
2026-6-16
|
| DOI |
10.1038/s41429-026-00929-9
|
| PII |
10.1038/s41429-026-00929-9
|
| PMID |
42303902
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
