論文 - 詳細
| RRC ID | 89382 |
|---|---|
| 著者 | Miki M, Shimazu Y, Obara RD, Nagamine T, Nakaya Y, Ikenaka Y, Osaki H, Kimura T, Hiono T, Isoda N, Shishido T, Sakoda Y. |
| タイトル | Assessment of a baloxavir marboxil treatment protocol for high pathogenicity avian influenza in Okinawa Rails, an endangered species endemic to Japan. |
| ジャーナル | PLoS One |
| Abstract |
High pathogenicity avian influenza (HPAI) is a highly infectious and lethal disease of birds that causes systemic symptoms and has been spreading globally, including in Japan. The Okinawa rail (Hypotaenidia okinawae), a flightless bird endemic to Japan, is classified as an endangered species on the Red List. In 2004, the Ministry of the Environment of Japan began implementing a conservation breeding program for Okinawa rails, focusing on maintaining the species' genetic diversity, captive breeding, and reintroduction to the wild. Given the potential for significant losses due to HPAI in Okinawa rails, the establishment of a treatment protocol as a preparedness measure is essential. The aim of this study was to determine an appropriate treatment method for HPAI in Okinawa rails using baloxavir marboxil (BXM), a drug shown to be effective in an avian laboratory model of HPAI virus infection. Single oral administration of BXM at 2.5 or 12.5 mg/kg did not produce plasma concentrations sufficient to achieve the expected therapeutic efficacy. Therefore, oral administration was deemed inadequate for generating the desired pharmacological effects. Consequently, subcutaneous administration of BXM to Okinawa rails at a dose of 2.5 or 7.5 mg/kg was explored as an alternative protocol, which resulted in higher systemic exposure compared with oral administration. Furthermore, plasma concentrations were maintained at therapeutically relevant levels up to 24 hours after subcutaneous administration at 7.5 mg/kg, with mild and reversible injection site irritation the main adverse effect. Based on these results, subcutaneous administration of BXM is proposed as a viable treatment protocol for HPAI in the conservation of endangered Okinawa rails. |
| 巻・号 | 21(3) |
| ページ | e0345055 |
| 公開日 | 2026-1-1 |
| DOI | 10.1371/journal.pone.0345055 |
| PII | PONE-D-25-38268 |
| PMID | 41871084 |
| PMC | PMC13008105 |
| MeSH | Animals Antiviral Agents* / administration & dosage Antiviral Agents* / pharmacokinetics Antiviral Agents* / pharmacology Antiviral Agents* / therapeutic use Birds* / virology Dibenzothiepins* Endangered Species* Influenza in Birds* / drug therapy Influenza in Birds* / virology Japan Morpholines Oxazines* / administration & dosage Oxazines* / pharmacokinetics Oxazines* / pharmacology Oxazines* / therapeutic use Pyridines* / administration & dosage Pyridines* / pharmacokinetics Pyridines* / pharmacology Pyridines* / therapeutic use Pyridones Thiepins* / administration & dosage Thiepins* / pharmacokinetics Thiepins* / pharmacology Thiepins* / therapeutic use Triazines* / administration & dosage Triazines* / pharmacokinetics Triazines* / pharmacology Triazines* / therapeutic use |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.6 |
| リソース情報 | |
| ヒト病原ウイルス | High pathogenicity avian influenza (HPAI) |