Reference - Detail
| RRC ID | 89407 |
|---|---|
| Author | Brimson CA, Baines R, Sams-Dodd E, Stefanescu I, Evans B, Kuwana S, Hashimura H, Sawai S, Thompson CRL. |
| Title | Collective oscillatory signaling in Dictyostelium discoideum acts as a developmental timer initiated by weak coupling of a noisy pulsatile signal. |
| Journal | Dev Cell |
| Abstract |
Oscillatory phenomena play widespread roles in the control of biological systems. In D. discoideum, oscillatory cyclic adenosine monophosphate (cAMP) signaling drives collective behavior and induces a temporal developmental gene expression program. How collective cAMP oscillations emerge or how they encode temporal transcriptional information is still poorly understood. To address this, we identified a transcription factor required for the initiation of collective behavior. Hbx5 activity is cAMP dependent and provides a sensitive single-cell readout for cAMP signaling. Extensive stochastic pulsatile cAMP signaling is found to precede collective oscillations. Stochastic signaling induces Hbx5-dependent transcriptional feedback, which enhances signal sensitivity and cell-cell coupling. This results in the emergence of synchronized collective oscillations, which subsequently activates the GtaC transcription factor and triggers shifts in developmental gene expression. Our results suggest this temporal coordination is encoded by changes in the amplitude of cAMP oscillations and differential sensitivity of these transcription factors to the cAMP-regulated kinase ErkB. |
| Volume | 60(6) |
| Pages | 918-933.e4 |
| Published | 2025-3-24 |
| DOI | 10.1016/j.devcel.2024.11.016 |
| PII | S1534-5807(24)00698-1 |
| PMID | 39672161 |
| MeSH | Cyclic AMP* / metabolism Dictyostelium* / genetics Dictyostelium* / growth & development Dictyostelium* / metabolism Gene Expression Regulation, Developmental Protozoan Proteins / genetics Protozoan Proteins / metabolism Signal Transduction* Transcription Factors / genetics Transcription Factors / metabolism |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Cellular slime molds | G90480 G90481 G90426 |