| RRC ID |
89432
|
| Author |
Nguyen TTN, Ngwe Tun MM, Vu TBH, Nguyen TTT, Hoang VMP, Nguyen LKH, Phan TL, Dang DA, Raekiansyah M, Suzuki R, Balingit JC, Takamatsu Y, Buerano CC, Urano T, Le TQM, Hasebe F, Morita K.
|
| Title |
Implications of immune responses to DENV, JEV, and ZIKV Infections for cross-reactivity and considerations for vaccine evaluation.
|
| Journal |
Virus Res
|
| Abstract |
Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are mosquito-borne flaviviruses of global concern, causing illnesses ranging from mild fever to severe neurological or hemorrhagic disease. Antibodies against these viruses exhibit complex cross-reactivity, influencing both neutralization and antibody-dependent enhancement (ADE). DENV comprises four serotypes (65-70% sequence identity) with multiple genotypes. Secondary heterologous infections increase the risk of dengue with or without warning signs and severe dengue, largely mediated by pre-existing antibodies from prior infection or vaccination. We assessed total antibody levels, neutralizing antibody (NAb) titers, and ADE activity of serum samples from Vietnamese patients with confirmed DENV infection and evaluated potential cross-reactivities with JEV and ZIKV. In primary infections, NAb titers were generally low (<1:10), except for JEV. Secondary infections showed the highest NAb titers against DENV-4, followed by DENV-2, DENV-3, and the lowest against DENV-1. In ADE assays, DENV-2 exhibited the highest enhancement, followed by DENV-1 and DENV-3, whereas DENV-4 showed minimal ADE. ADE was also detected for JEV and ZIKV, demonstrating that cross-reactive antibodies can facilitate infection across flaviviruses. These findings underscore the impact of pre-existing cross-reactive antibodies in endemic regions and highlight the importance of evaluating vaccine-induced cross-reactive immunity.
|
| Volume |
364
|
| Pages |
199689
|
| Published |
2026-2-1
|
| DOI |
10.1016/j.virusres.2026.199689
|
| PII |
S0168-1702(26)00006-7
|
| PMID |
41519272
|
| PMC |
PMC12835417
|
| MeSH |
Animals
Antibodies, Neutralizing / blood
Antibodies, Neutralizing / immunology
Antibodies, Viral* / blood
Antibodies, Viral* / immunology
Antibody-Dependent Enhancement
Cross Reactions
Dengue* / immunology
Dengue* / prevention & control
Dengue* / virology
Dengue Vaccines / immunology
Dengue Virus* / immunology
Encephalitis Virus, Japanese* / immunology
Encephalitis, Japanese* / immunology
Encephalitis, Japanese* / prevention & control
Encephalitis, Japanese* / virology
Humans
Neutralization Tests
Serogroup
Vietnam
Viral Vaccines* / immunology
Zika Virus* / immunology
Zika Virus Infection* / immunology
Zika Virus Infection* / prevention & control
Zika Virus Infection* / virology
|
| Resource |
| Human pathogenic viruses |
|
