| RRC ID |
89434
|
| 著者 |
Yu D, Gao X, Shao F, Liu Z, Liu A, Zhao M, Tang Z, Guan Y, Wang S.
|
| タイトル |
Antigen-presenting innate lymphoid cells induced by BCG vaccination promote a respiratory antiviral immune response through the skin‒lung axis.
|
| ジャーナル |
Cell Mol Immunol
|
| Abstract |
The route of vaccine administration is associated with various immune outcomes, and the relationship between the route of administration and broad protection against heterologous pathogens remains unclear. Here, we found that subcutaneous vaccination with Bacillus Calmette-Guérin (BCG) promotes respiratory influenza clearance and T-cell responses. Group 1 innate lymphoid cells (ILC1s) express MHCII molecules and engage in antigen processing and presentation after BCG vaccination. During influenza virus infection, ILC1s in the lungs of BCG-vaccinated mice can present influenza virus antigens and prime Th1 cells. After subcutaneous vaccination with BCG, MHCII+ ILC1s migrate from the skin to the lungs and play an antigen-presenting role in influenza infection. Both the BCG and the BCG component lipomannan can induce MHCII expression and skin-to-lung migration of ILC1s via TLR2 signaling. Our study revealed an important regulatory mechanism by which subcutaneous vaccination with BCG promotes respiratory antiviral immune responses via the skin‒lung axis.
|
| 巻・号 |
22(4)
|
| ページ |
390-402
|
| 公開日 |
2025-4-1
|
| DOI |
10.1038/s41423-025-01267-w
|
| PII |
10.1038/s41423-025-01267-w
|
| PMID |
39962263
|
| PMC |
PMC11955553
|
| MeSH |
Animals
Antigen Presentation
Antigen-Presenting Cells* / immunology
BCG Vaccine* / immunology
Female
Immunity, Innate*
Lung* / immunology
Lung* / virology
Lymphocytes* / immunology
Mice
Mice, Inbred C57BL
Orthomyxoviridae Infections* / immunology
Skin* / immunology
Toll-Like Receptor 2 / metabolism
Vaccination*
|
| リソース情報 |
| 実験動物マウス |
RBRC09256 |
