| RRC ID |
89457
|
| 著者 |
Dong Y, Rahaman SM, Zhu W, Inutsuka A, Ono D, Tanaka R, Matsuzaki T, Shibata E, Isobe M, Izawa S, Yamanaka A, Yamada K, Mizoguchi H.
|
| タイトル |
Reward prediction is encoded by orexin neuron activity during motivated behavior.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
Orexin neurons regulate physiological functions, such as energy homeostasis, wakefulness, and motivated behaviors. However, studies linking orexin neuron activity to behavior via selectively activating/inactivating these inputs in a temporally controlled manner in rats are scarce. Here, we examined the role that orexin neurons play in motivated behavior in transgenic rats using cell type-specific fiber photometry and optogenetic manipulation. Using chemogenetics, we found that motivation for a reward increased when orexin neurons were activated. Furthermore, during motivated behavior, orexin neuron activity changed dynamically: Activity increased during reward prediction and decreased after reward receipt. When an unexpected event occurred (i.e., not obtaining an expected reward), increased orexin activity was sustained. Notably, orexin activity strengthened with increasing effort. Optogenetic inhibition of orexin neuron activation during reward prediction and treatment with an orexin 1-receptor antagonist reduced reward-seeking behavior. Therefore, orexin is crucial for linking predicted expectations with motivated behavior. Moreover, optimization of orexin activity is necessary to overcome difficulties during motivated behaviors.
|
| 巻・号 |
123(27)
|
| ページ |
e2520677123
|
| 公開日 |
2026-7-7
|
| DOI |
10.1073/pnas.2520677123
|
| PMID |
42372152
|
| MeSH |
Animals
Behavior, Animal* / physiology
Male
Motivation* / physiology
Neurons* / metabolism
Neurons* / physiology
Optogenetics
Orexin Receptor Antagonists / pharmacology
Orexin Receptors / metabolism
Orexins* / genetics
Orexins* / metabolism
Rats
Rats, Transgenic
Reward*
|
| リソース情報 |
| ラット |
LE-Tg(Gt(ROSA)26Sor-CAG-tdTomato)24Jfhy (StrainID=1139) |
