Reference - Detail
| RRC ID | 89471 |
|---|---|
| Author | Morita S, Ota R, Hayashi M, Kobayashi S. |
| Title | Repression of G1/S Transition by Transient Inhibition of miR-10404 Expression in Drosophila Primordial Germ Cells. |
| Journal | iScience |
| Abstract |
Cell-cycle quiescence is a common feature of early germline development in many animal species. In Drosophila germline progenitors (pole cells), both G2/M and G1/S transitions are blocked. G2/M transition is repressed by maternal Nanos through suppression of Cyclin B production. However, the molecular mechanism underlying blockage of G1/S transition remains elusive. We found that repression of miR-10404 expression is required to block G1/S transition in pole cells. Expression of miR-10404, a microRNA encoded within the internal transcribed spacer 1 of rDNA, is repressed in early pole cells by maternal polar granule component. This repression delays the degradation of maternal dacapo mRNA, which encodes an inhibitor of G1/S transition. Moreover, derepression of G1/S transition in pole cells causes defects in their maintenance and their migration into the gonads. Our observations reveal the mechanism inhibiting G1/S transition in pole cells and its requirement for proper germline development. |
| Volume | 23(3) |
| Pages | 100950 |
| Published | 2020-3-27 |
| DOI | 10.1016/j.isci.2020.100950 |
| PII | S2589-0042(20)30134-6 |
| PMID | 32179474 |
| PMC | PMC7075979 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#119883 |