Reference - Detail
| RRC ID | 89527 |
|---|---|
| Author | Shamskhou EA, Duffy FJ, Cross LM, Plumlee CR, Gern BH, Barrett HW, Diercks AH, Cohen SB, Sivakumar R, Aitchison JD, Ganusov VV, Urdahl KB, Gerner MY. |
| Title | Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes. |
| Journal | Immunity |
| Abstract |
Lung-draining mediastinal lymph nodes (medLNs) are critical for Mycobacterium tuberculosis (Mtb) pathogenesis, serving both as sites of T cell priming and, paradoxically, reservoirs for long-term bacterial persistence. To understand this dichotomy, we examined myeloid and CD4+ T cell dynamics in medLNs after aerosol Mtb infection. Early bacterial dissemination occurred via monocytes and interleukin (IL)-12-producing conventional dendritic cells (cDCs), which initiated T helper 1 (Th1) cell priming within the T cell zone. Over time, cDC migration and T cell activation declined, and medLNs became dominated by heavily infected monocyte-derived aggregates that persisted into late infection. Despite inducing proinflammatory and bactericidal pathways, these aggregates escaped recognition by Mtb-specific T cells and failed to clear Mtb, thereby forming an immunologically "blind" niche. Bacille Calmette-Guérin (BCG) vaccination reduced Mtb burden and niche establishment without altering myeloid trafficking or T cell priming. Thus, Mtb persists in medLNs within monocytic niches, eliciting classical antimicrobial programs that are insufficient for sterilizing control. |
| Published | 2026-6-23 |
| DOI | 10.1016/j.immuni.2026.05.017 |
| PII | S1074-7613(26)00228-1 |
| PMID | 42335893 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 39 |
| Altmetric score changes over past 6months | 19.5 |
| Resource | |
| Mice | RBRC09485 |