| RRC ID |
89560
|
| Author |
Yamaguchi M, Hitaka Y, Tsuji S, Ogawa M, Takemoto K, Sakamoto A, Yamada Y, Isoyama N, Shiraishi K, Asagiri M.
|
| Title |
Renoprotective effects of gut NHE3 inhibitor tenapanor in a rat model of unilateral renal ischemia-reperfusion injury with contralateral nephrectomy.
|
| Journal |
Biochem Biophys Rep
|
| Abstract |
Kidney ischemia-reperfusion (I/R) injury is an unavoidable complication of kidney transplantation that contributes to acute kidney injury (AKI), chronic kidney disease (CKD), and limited long-term graft survival. Elevated serum phosphate has been implicated not only as a consequence of renal dysfunction but also as an active mediator of kidney injury. Tenapanor, an intestinal sodium/hydrogen exchanger 3 inhibitor approved for the treatment of hyperphosphatemia in dialysis patients, may therefore have renoprotective potential; however, its effects on renal I/R injury remain unclear. Here, we show that oral administration of tenapanor suppresses renal calcium phosphate deposition after I/R, mitigates AKI progression, and reduces subsequent renal fibrosis in rats. These findings suggest that tenapanor mitigates renal I/R injury and may represent a potential pre-transplant strategy to improve long-term graft outcomes.
|
| Volume |
47
|
| Pages |
102711
|
| Published |
2026-9-1
|
| DOI |
10.1016/j.bbrep.2026.102711
|
| PII |
S2405-5808(26)00271-2
|
| PMID |
42471818
|
| PMC |
PMC13380000
|
| Resource |
| Human and Animal Cells |
MDCK-II(RCB5148) |
