論文 - 詳細
| RRC ID | 89629 |
|---|---|
| 著者 | Trinh AT, Ostenrath AM, Del Castillo-Berges I, Cachin F, Koç M, Kraus S, Serneels B, Kawakami K, Yaksi E. |
| タイトル | Hierarchical sensory processing in zebrafish thalamocortical-like circuits. |
| ジャーナル | Science |
| Abstract |
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian vertebrates remain underexplored. Here we investigated how the zebrafish pallium, a homolog of the vertebrate cortex, receives and processes sensory information, and how its architecture compares to thalamocortical circuits in other vertebrates. We revealed that the preglomerular complex (PG), a thalamocortical-like pathway, is the primary source of visual and vibrational information to the zebrafish pallium. PG and its pallial projections exhibit sensory-specific and topographically organized responses. In contrast, pallial neurons display topographically organized hierarchies, ranging from sensory-specific to multimodal and coincidence-detecting nonlinear responses. Our results suggest that hierarchies of sensory transformations across topographically organized thalamocortical-like circuits reflect a convergent principle across vertebrates. |
| ページ | eaec2171 |
| 公開日 | 2026-7-2 |
| DOI | 10.1126/science.aec2171 |
| PMID | 42391324 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 45.0 |
| リソース情報 | |
| ゼブラフィッシュ | gSAIzGFFD707A, UAS:GCaMP6s |