| RRC ID |
89629
|
| 著者 |
Trinh AT, Ostenrath AM, Del Castillo-Berges I, Cachin F, Koç M, Kraus S, Serneels B, Kawakami K, Yaksi E.
|
| タイトル |
Hierarchical sensory processing in zebrafish thalamocortical-like circuits.
|
| ジャーナル |
Science
|
| Abstract |
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian vertebrates remain underexplored. Here we investigated how the zebrafish pallium, a homolog of the vertebrate cortex, receives and processes sensory information, and how its architecture compares to thalamocortical circuits in other vertebrates. We revealed that the preglomerular complex (PG), a thalamocortical-like pathway, is the primary source of visual and vibrational information to the zebrafish pallium. PG and its pallial projections exhibit sensory-specific and topographically organized responses. In contrast, pallial neurons display topographically organized hierarchies, ranging from sensory-specific to multimodal and coincidence-detecting nonlinear responses. Our results suggest that hierarchies of sensory transformations across topographically organized thalamocortical-like circuits reflect a convergent principle across vertebrates.
|
| ページ |
eaec2171
|
| 公開日 |
2026-7-2
|
| DOI |
10.1126/science.aec2171
|
| PMID |
42391324
|
| リソース情報 |
| ゼブラフィッシュ |
gSAIzGFFD707A, UAS:GCaMP6s |
